PT-141 (Bremelanotide)
฿900.00
- Mechanism: MC3R/MC4R agonist; CNS-active cyclic melanocortin peptide with central signaling selectivity
- Format: Lyophilized powder, 10mg per vial, >99% purity by HPLC
- Included: Vial + Certificate of Analysis (HPLC + mass spectrum)
For research use only. Not for human or veterinary consumption. In-vitro laboratory use only.
Description
Product Specifications
| Peptide | PT-141 (Bremelanotide) |
|---|---|
| Also known as | Bremelanotide • PT141 |
| CAS Number | 189691-06-3 |
| Molecular Weight | 1,025.18 Da |
| Quantity per vial | 10mg |
| Format | Lyophilized powder (white to off-white) |
| Purity | >99% by HPLC |
| Peptide content | ≥90% net peptide (adjusted for water and counter-ions) |
| Verification method | External HPLC chromatography + mass spectrometry |
| Certificate of Analysis | Provided digitally with every shipment |
| Reconstitution | Bacteriostatic water |
| Storage — lyophilized | −20°C, sealed vial, away from moisture and light |
| Storage — in solution | −80°C; use within 30 days; avoid freeze-thaw cycles |
| Shelf life | 24 months from manufacture date (lyophilized, correct storage) |
| Intended use | In-vitro laboratory research only. Not for human or veterinary use. |
Research Background
PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide derived from the Melanotan II structure. Unlike its parent compound, PT-141 lacks the acetyl group at the N-terminus, resulting in a different receptor selectivity profile. It acts primarily as an agonist at MC3R and MC4R and has been used as a pharmacological probe for central melanocortin signaling, distinct from peripheral pigmentation pathways driven by MC1R.
PT-141 has been studied in hypothalamic and limbic system models for its role in neuropeptide signaling. Because it acts through CNS melanocortin receptors rather than peripheral vasodilatory mechanisms, it represents a useful research tool for probing energy homeostasis and central autonomic regulation in cell and tissue models.
Research Applications
- MC3R/MC4R-selective agonist binding studies using competitive radioligand displacement assays
- cAMP accumulation and PKA signaling quantification downstream of MC receptor activation
- Hypothalamic neuropeptide signaling network characterization
- Comparative receptor selectivity profiling: PT-141 vs. MT-II vs. α-MSH
- Energy homeostasis-related receptor pathway mapping in neuronal cell lines
- Receptor internalization and desensitization kinetics (GPCR trafficking studies)
- ERK1/2 activation and β-arrestin recruitment assays in melanocortin receptor-expressing cell lines
Reconstitution Protocol
Allow the vial to equilibrate to room temperature before opening. Reconstitute in bacteriostatic water at the required working concentration. Do not vortex; gently swirl until the powder is fully dissolved. Filter through a 0.22 μm membrane if sterile conditions are needed for cell work. Aliquot into single-use volumes immediately after reconstitution to avoid freeze-thaw cycling.
Storage and Stability
Store lyophilized vials at −20°C in the original sealed container, protected from moisture and light. Lyophilized material stays stable for up to 24 months from the manufacture date shown on the Certificate of Analysis. Reconstituted solutions should be stored at −80°C and used within 30 days. Avoid repeated freeze-thaw cycles, which degrade the peptide over time.
What’s Included
- 1 × PT-141 lyophilized vial — 10mg
- Independent Certificate of Analysis (HPLC chromatogram + mass spectrum + batch data)
- Batch number and expiry date printed on vial label
- Discreet external packaging with no product name or branding on the exterior
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