Melanotan II
฿800.00
- Mechanism: Non-selective MC1R/MC4R agonist; cyclic alpha-MSH analog with high enzymatic stability
- Format: Lyophilized powder, 10mg per vial, >99% purity by HPLC
- Included: Vial + Certificate of Analysis (HPLC + mass spectrum)
For research use only. Not for human or veterinary consumption. In-vitro laboratory use only.
Description
Product Specifications
| Peptide | Melanotan II |
|---|---|
| Also known as | MT-2 • MT-II • cyclic MSH analog |
| CAS Number | 121062-08-6 |
| Molecular Weight | 1,024.18 Da |
| Quantity per vial | 10mg |
| Format | Lyophilized powder (white to off-white) |
| Purity | >99% by HPLC |
| Peptide content | ≥90% net peptide (adjusted for water and counter-ions) |
| Verification method | External HPLC chromatography + mass spectrometry |
| Certificate of Analysis | Provided digitally with every shipment |
| Reconstitution | Bacteriostatic water |
| Storage — lyophilized | −20°C, sealed vial, away from moisture and light |
| Storage — in solution | −80°C; use within 30 days; avoid freeze-thaw cycles |
| Shelf life | 24 months from manufacture date (lyophilized, correct storage) |
| Intended use | In-vitro laboratory research only. Not for human or veterinary use. |
Research Background
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It was developed at the University of Arizona as part of research into melanocortin receptor pharmacology. The cyclic structure confers greater resistance to enzymatic degradation than the linear α-MSH parent molecule. MT-II acts as a non-selective agonist at the melanocortin receptor family, with high affinity at MC1R and MC4R and moderate affinity at MC3R and MC5R.
In cell culture models, MC4R activation has been associated with suppression of food intake-related signaling, while MC1R activity mediates melanogenesis in melanocyte cell lines. The CNS-penetrant properties of the molecule make it a useful tool compound for studying central melanocortin signaling in vitro through receptor binding assays and downstream cAMP pathway characterization.
Research Applications
- Melanocortin receptor binding affinity studies (MC1R, MC3R, MC4R, MC5R) using competitive radioligand assays
- cAMP second-messenger quantification downstream of MC receptor activation in cultured cell lines
- Melanogenesis assays in B16F10 or primary melanocyte cell cultures
- Food intake and energy balance-related neuropeptide receptor characterization
- ERK1/2 and PKA phosphorylation mapping in melanocortin pathway studies
- Comparative potency profiling vs. α-MSH, MT-II analogs, and selective MCR agonists
- MC4R internalization and receptor trafficking studies using fluorescent reporter systems
Reconstitution Protocol
Allow the vial to equilibrate to room temperature before opening. Reconstitute in bacteriostatic water at the required working concentration. Do not vortex; swirl gently until the powder is fully dissolved. For sterile cell-based work, filter through a 0.22 μm membrane. Prepare single-use aliquots immediately after reconstitution to eliminate freeze-thaw degradation.
Storage and Stability
Store lyophilized vials at −20°C in the original sealed container, protected from moisture and light. Lyophilized material stays stable for up to 24 months from the manufacture date shown on the Certificate of Analysis. Reconstituted solutions should be stored at −80°C and used within 30 days. Avoid repeated freeze-thaw cycles, which degrade the peptide over time.
What’s Included
- 1 × Melanotan II lyophilized vial — 10mg
- Independent Certificate of Analysis (HPLC chromatogram + mass spectrum + batch data)
- Batch number and expiry date printed on vial label
- Discreet external packaging with no product name or branding on the exterior
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