Epitalon
฿1,800.00
- Mechanism: Pineal tetrapeptide (Ala-Glu-Asp-Gly) with telomerase-activating and antioxidant signaling properties
- Format: Lyophilized powder, 10mg per vial, >99% purity by HPLC
- Included: Vial + Certificate of Analysis (HPLC + mass spectrum)
For research use only. Not for human or veterinary consumption. In-vitro laboratory use only.
Description
Product Specifications
| Peptide | Epitalon (Epithalon) |
|---|---|
| Sequence | Ala-Glu-Asp-Gly |
| CAS Number | 307297-39-8 |
| Molecular Weight | 390.35 Da |
| Quantity per vial | 10mg |
| Format | Lyophilized powder (white to off-white) |
| Purity | >99% by HPLC |
| Peptide content | ≥90% net peptide (adjusted for water and counter-ions) |
| Verification method | External HPLC chromatography + mass spectrometry |
| Certificate of Analysis | Provided digitally with every shipment |
| Reconstitution | Sterile water for injection |
| Storage — lyophilized | −20°C, sealed vial, away from moisture and light |
| Storage — in solution | −80°C; use within 30 days; avoid freeze-thaw cycles |
| Shelf life | 24 months from manufacture date (lyophilized, correct storage) |
| Intended use | In-vitro laboratory research only. Not for human or veterinary use. |
Research Background
Epitalon (also written Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from a pineal gland peptide fraction known as epithalamin. It was first described by the research group of Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. The natural fraction was found in a series of studies to stimulate melatonin production in pinealocytes and to exhibit telomerase-activating properties in cultured fibroblasts and lymphocytes.
In-vitro studies have reported that epitalon stimulates telomerase activity in human somatic cells — including retinal epithelial cells, fetal fibroblasts, and lymphocytes — resulting in telomere elongation and extended replicative lifespan in cell culture. It has also been studied for effects on antioxidant enzyme expression and for modulation of melatonin synthesis in pinealocyte-derived cell models. The mechanism by which the tetrapeptide activates telomerase remains under investigation, with chromatin remodeling and transcriptional regulation proposed as contributing pathways.
Research Applications
- Telomerase activity assays (TRAP assay) in human fibroblast, lymphocyte, and epithelial cell lines
- Telomere length quantification following chronic epitalon treatment in replicative aging models
- Pinealocyte melatonin synthesis and secretion studies
- Antioxidant enzyme expression profiling (SOD1, SOD2, catalase, GPx) under epitalon treatment
- Cellular senescence marker characterization (β-galactosidase, p21, p53) in aging cell models
- Replicative lifespan extension studies in primary cell culture
- Chromatin remodeling and gene expression effects of pineal-derived tetrapeptide sequences
Reconstitution Protocol
Allow the vial to equilibrate to room temperature before opening. Reconstitute in sterile water for injection at the required working concentration. Do not vortex; gently swirl or invert the vial until fully dissolved. Filter through a 0.22 μm sterile membrane if sterility is required for cell-based assays. Aliquot into single-use volumes before freezing to minimize freeze-thaw exposure.
Storage and Stability
Store lyophilized vials at −20°C in the original sealed container, protected from moisture and light. Lyophilized material stays stable for up to 24 months from the manufacture date shown on the Certificate of Analysis. Reconstituted solutions should be stored at −80°C and used within 30 days. Avoid repeated freeze-thaw cycles, which degrade the peptide over time.
What’s Included
- 1 × Epitalon lyophilized vial — 10mg
- Independent Certificate of Analysis (HPLC chromatogram + mass spectrum + batch data)
- Batch number and expiry date printed on vial label
- Discreet external packaging with no product name or branding on the exterior
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