DSIP (Delta Sleep-Inducing Peptide)
฿900.00
- Mechanism: Endogenous sleep-regulatory nonapeptide modulating HPA axis and slow-wave sleep pathways
- Format: Lyophilized powder, 5mg per vial, >99% purity by HPLC
- Included: Vial + Certificate of Analysis (HPLC + mass spectrum)
For research use only. Not for human or veterinary consumption. In-vitro laboratory use only.
Description
Product Specifications
| Peptide | DSIP (Delta Sleep-Inducing Peptide) |
|---|---|
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| CAS Number | 62568-57-4 |
| Molecular Weight | 848.93 Da |
| Quantity per vial | 5mg |
| Format | Lyophilized powder (white to off-white) |
| Purity | >99% by HPLC |
| Peptide content | ≥90% net peptide (adjusted for water and counter-ions) |
| Verification method | External HPLC chromatography + mass spectrometry |
| Certificate of Analysis | Provided digitally with every shipment |
| Reconstitution | Sterile water for injection |
| Storage — lyophilized | −20°C, sealed vial, away from moisture and light |
| Storage — in solution | −80°C; use within 30 days; avoid freeze-thaw cycles |
| Shelf life | 24 months from manufacture date (lyophilized, correct storage) |
| Intended use | In-vitro laboratory research only. Not for human or veterinary use. |
Research Background
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit thalamic perfusate in 1977 by Schoenenberger and colleagues. Its endogenous distribution spans the hypothalamus, limbic system, pituitary gland, and peripheral tissues including the gonads and pancreas. DSIP does not map to a single characterized receptor; it is thought to act through multiple GPCRs and ion channels depending on tissue context.
Published in-vitro research has examined its effects on hypothalamic-pituitary-adrenal (HPA) axis modulation, including impacts on CRH secretion and ACTH release in pituitary cell cultures. Additional studies have investigated its role in circadian rhythm regulation, mitochondrial function, and oxidative stress attenuation, making DSIP a useful tool compound for broad neuroendocrine signaling research.
Research Applications
- HPA axis modulation studies in hypothalamic and pituitary cell line models
- CRH and ACTH secretion assays in primary pituitary cultures
- Circadian rhythm and chronobiological signaling pathway investigation
- Mitochondrial membrane potential and oxidative stress assays in neuronal cell models
- Sleep-regulatory neuropeptide comparative profiling studies
- Antioxidant enzyme expression (SOD, catalase) modulation characterization
- GPCR signaling studies across neuroendocrine receptor panels
Reconstitution Protocol
Allow the vial to reach room temperature before opening. Reconstitute in sterile water for injection at your required assay concentration. Do not vortex; gently invert or swirl until fully dissolved. Filter through a 0.22 μm sterile membrane if sterility is critical for cell-based assays. Aliquot immediately into single-use volumes to protect against freeze-thaw degradation.
Storage and Stability
Store lyophilized vials at −20°C in the original sealed container, protected from moisture and light. Lyophilized material stays stable for up to 24 months from the manufacture date shown on the Certificate of Analysis. Reconstituted solutions should be stored at −80°C and used within 30 days. Avoid repeated freeze-thaw cycles, which degrade the peptide over time.
What’s Included
- 1 × DSIP lyophilized vial — 5mg
- Independent Certificate of Analysis (HPLC chromatogram + mass spectrum + batch data)
- Batch number and expiry date printed on vial label
- Discreet external packaging with no product name or branding on the exterior
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